ZFIN ID: ZDB-PUB-040709-1
Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits
Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R.
Date: 2004
Source: Science (New York, N.Y.)   305(5681): 254-258 (Journal)
Registered Authors: Bhatt, Dimple, Fetcho, Joseph R.
Keywords: none
MeSH Terms:
  • Animals
  • Axons/drug effects
  • Axons/physiology*
  • Bucladesine/pharmacology*
  • Calcium/metabolism
  • Cyclic AMP/analogs & derivatives
  • Cyclic AMP/pharmacology
  • Electroporation
  • Escape Reaction
  • Fluorescent Dyes
  • Interneurons/physiology
  • Microscopy, Confocal
  • Nerve Regeneration*
  • Neurons/drug effects
  • Neurons/physiology*
  • Regeneration
  • Rhodamines
  • Spinal Cord/cytology*
  • Spinal Cord Injuries/drug therapy*
  • Spinal Cord Injuries/physiopathology*
  • Zebrafish
PubMed: 15247482 Full text @ Science
to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.