|ZFIN ID: ZDB-PUB-040709-1|
Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits
Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R.
|Source:||Science (New York, N.Y.) 305(5681): 254-258 (Journal)|
|Registered Authors:||Bhatt, Dimple, Fetcho, Joseph R.|
|PubMed:||15247482 Full text @ Science|
Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R. (2004) Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits. Science (New York, N.Y.). 305(5681):254-258.
ABSTRACTto regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.
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