ZFIN ID: ZDB-PUB-040609-5
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish
Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.
Date: 2004
Source: Gene expression patterns : GEP   4(4): 481-486 (Journal)
Registered Authors: Bae, Young Ki, Hibi, Masahiko, Hirata, Tsutomu, Muraoka, Osamu, Nojima, Hideaki, Shimizu, Takashi, Yabe, Taijirou
Keywords: Homeobox, Neuroectoderm, Floor plate, Zebrafish
MeSH Terms:
  • Animals
  • Central Nervous System/embryology*
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology*
  • Homeodomain Proteins/biosynthesis*
  • Homeodomain Proteins/genetics
  • Humans
  • Molecular Sequence Data
  • Nodal Protein
  • Signal Transduction/physiology
  • Transcription Factors/biosynthesis*
  • Transcription Factors/genetics
  • Transforming Growth Factor beta/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/biosynthesis*
  • Zebrafish Proteins/genetics
PubMed: 15183316 Full text @ Gene Expr. Patterns
sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord.