ZFIN ID: ZDB-PUB-040421-3
Towing of sensory axons by their migrating target cells in vivo
Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C.
Date: 2004
Source: Nature Neuroscience   7(5): 491-492 (Journal)
Registered Authors: Gilmour, Darren, Knaut, Holger, Maischein, Hans-Martin, Nüsslein-Volhard, Christiane
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Axons/physiology*
  • Cell Communication/genetics*
  • Cell Movement/physiology*
  • Chemokine CXCL12
  • Chemokines, CXC/metabolism
  • Diagnostic Imaging/methods
  • Embryo, Nonmammalian
  • Green Fluorescent Proteins
  • Growth Cones
  • In Situ Hybridization/methods
  • Luminescent Proteins
  • Neurons, Afferent/cytology
  • Neurons, Afferent/physiology*
  • Neurons, Afferent/transplantation
  • Receptors, CXCR4/genetics
  • Signal Transduction
  • Time Factors
  • Transplantation/methods
  • Zebrafish
  • Zebrafish Proteins/genetics
PubMed: 15097993 Full text @ Nat. Neurosci.
Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.