PUBLICATION
Autonomous modes of behavior in primordial germ cell migration
- Authors
- Reichman-Fried, M., Minina, S., and Raz, E.
- ID
- ZDB-PUB-040408-1
- Date
- 2004
- Source
- Developmental Cell 6(4): 589-596 (Journal)
- Registered Authors
- Minina, Sofia, Raz, Erez, Reichman-Fried, Michal
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Communication/genetics
- Cell Differentiation/genetics
- Cell Movement/genetics*
- Cell Polarity/genetics
- Chemokine CXCL12
- Chemokines, CXC/genetics
- Chemokines, CXC/metabolism
- Chemotaxis/genetics
- Cues
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology*
- Embryo, Nonmammalian/physiology
- Gene Expression Regulation, Developmental/genetics
- Genitalia/cytology
- Genitalia/embryology*
- Genitalia/physiology
- Germ Cells/cytology
- Germ Cells/physiology*
- Organogenesis/genetics*
- Zebrafish/embryology*
- PubMed
- 15068797 Full text @ Dev. Cell
Citation
Reichman-Fried, M., Minina, S., and Raz, E. (2004) Autonomous modes of behavior in primordial germ cell migration. Developmental Cell. 6(4):589-596.
Abstract
Zebrafish primordial germ cells (PGCs) are guided toward their targets by the chemokine SDF-1a. PGCs were followed during three phases of their migration: when migrating as individual cells, while remaining in a clustered configuration, and when moving as a cell cluster within the embryo. We found that individually migrating PGCs alternate between migratory and pausing modes. Pausing intervals are characterized by loss of cell polarity and correlate with subsequent changes in the direction of migration. These properties constitute an intrinsic behavior of PGCs, enabling erasure of prior polarity and re-sampling of the environment. Following migration arrest at a site of high SDF-1a levels, PGCs resume migration as a cluster. The seemingly coordinated cluster migration is a result of single-cell movement in response to local variations in SDF-1a distribution. Together, these behavioral modes allow the cells to arrive at specific destinations with high fidelity and remain at their target site.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping