Retinal pattern and the genetic basis of its formation in zebrafish
- Pujic, Z., and Malicki, J.
- Seminars in cell & developmental biology 15(1): 105-114 (Journal)
- Registered Authors
- Malicki, Jarema, Pujic, Zac
- Eye, Mutant, Patterning, Retina, Zebrafish
- MeSH Terms
- Cell Differentiation/genetics
- Cell Differentiation/physiology
- Central Nervous System/cytology
- Central Nervous System/embryology
- Central Nervous System/metabolism
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/metabolism
- Eye/anatomy & histology
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Models, Biological
- Protein Kinase C/physiology
- Retina/anatomy & histology
- 15036213 Full text @ Sem. Cell Dev. Biol.
Pujic, Z., and Malicki, J. (2004) Retinal pattern and the genetic basis of its formation in zebrafish. Seminars in cell & developmental biology. 15(1):105-114.
The vertebrate nervous system contains an immense diversity of distinct cellular components that are organized into precise spatial patterns. The importance of accurate neuronal architecture is particularly obvious in the retina, where it is necessary for the formation of visual images. The retina is structured in a distinct layered pattern that is remarkably conserved in evolution, including phyla as diverse as primates and teleost fish. Genetic analysis in zebrafish reveals mechanisms that are essential for the formation of this architecture.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes