ZFIN ID: ZDB-PUB-040319-2
Muscle differentiation: a gene for slow muscle?
Hughes, S.M.
Date: 2004
Source: Current biology : CB   14(4): 156-157 (Journal)
Registered Authors: Hughes, Simon M.
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • Hedgehog Proteins
  • Muscle Development*
  • Muscle Fibers, Slow-Twitch/metabolism
  • Muscle Fibers, Slow-Twitch/physiology*
  • Muscle, Skeletal/embryology*
  • Myoblasts, Skeletal/cytology*
  • Nuclear Proteins
  • Repressor Proteins/genetics
  • Repressor Proteins/metabolism*
  • Trans-Activators/metabolism
  • Transcription Factors/genetics
  • Transcription Factors/metabolism*
  • Zebrafish
  • Zebrafish Proteins
PubMed: 15027468 Full text @ Curr. Biol.
Skeletal muscle comes in two fundamental flavours, slow and fast, which determine physiological performance. Zebrafish screens have provided a handle on the molecular mechanism driving slow muscle formation. The transcriptional repressor Blimp1 has now been shown to be required in embryonic slow muscle precursor cells.