PUBLICATION
Isolation and expression of the homeobox gene Gbx1 during mouse development
- Authors
- Rhinn, M., Lun, K., Werner, M., Simeone, A., and Brand, M.
- ID
- ZDB-PUB-040211-3
- Date
- 2004
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 2: 334-339 (Journal)
- Registered Authors
- Brand, Michael, Geffarth, Michaela, Lun, Klaus, Rhinn, Muriel
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Early Growth Response Protein 2
- Embryonic and Fetal Development/genetics
- Embryonic and Fetal Development/physiology*
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology*
- Genes, Homeobox*
- Homeodomain Proteins/genetics*
- Homeodomain Proteins/metabolism
- In Situ Hybridization
- Mice
- Molecular Sequence Data
- Morphogenesis/genetics
- Organ Specificity
- Sequence Alignment
- Transcription Factors/genetics
- Transcription Factors/metabolism
- Zebrafish Proteins
- PubMed
- 14745958 Full text @ Dev. Dyn.
Citation
Rhinn, M., Lun, K., Werner, M., Simeone, A., and Brand, M. (2004) Isolation and expression of the homeobox gene Gbx1 during mouse development. Developmental Dynamics : an official publication of the American Association of Anatomists. 2:334-339.
Abstract
In zebrafish, gbx1 and otx2 are among the earliest genes expressed in the neuroectoderm, dividing it into an anterior and a posterior domain with a common border that marks the midbrain-hindbrain boundary (MHB) primordium. Here, we describe the sequence and expression pattern of Gbx1 in mouse. The first transcripts are found at embryonic day 7.75 in the hindbrain. Later on, expression of Gbx1 is detectable in the hindbrain (rhombomeres 2 to 7), spinal cord, optic vesicles, and in the ventral telencephalon. In mouse, Gbx1 expression is not observed at the MHB as is the case during early zebrafish development. We suggest that an evolutionary switch occurred: in mouse Gbx2 is involved in the early specification of the MHB primordium, whereas in zebrafish, gbx1 is required instead of gbx2. Developmental Dynamics 229:334-339, 2004. Copyright 2004 Wiley-Liss, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping