PUBLICATION
Modularity and reshuffling of Snail and Slug expression during vertebrate evolution
- Authors
- Locascio, A., Manzanares, M., Blanco, M.J., and Nieto, M.A.
- ID
- ZDB-PUB-040103-1
- Date
- 2002
- Source
- Proceedings of the National Academy of Sciences of the United States of America 99(26): 16841-16846 (Journal)
- Registered Authors
- Nieto, Angela
- Keywords
- none
- MeSH Terms
-
- Animals
- Chick Embryo
- DNA-Binding Proteins/genetics*
- Evolution, Molecular
- Gene Duplication*
- In Situ Hybridization
- Mice
- Phylogeny
- Transcription Factors/genetics*
- Turtles
- Vertebrates
- Zebrafish
- PubMed
- 12482931 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Locascio, A., Manzanares, M., Blanco, M.J., and Nieto, M.A. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16841-16846.
Abstract
Gene duplication has been a major mechanism for increasing genomic complexity and variation during evolution. The evolutionary history of duplicated genes has been poorly studied along the vertebrate lineage. Here, we attempt to study that history by analyzing the expression of two members of the Snail family, Snail and Slug, in representatives of the major vertebrate groups. We find a surprising degree of variability in a subset of the expression sites for both genes in different species. Although some of the changes can be explained by neofunctionalization or subfunctionalization, others imply reciprocal changes in the expression of the two genes and the reappearance of expression in sites lost earlier in evolution. Because these changes do not fit easily into current models, we need to invoke additional mechanisms acting on enhancer elements to distribute expression domains and functions of duplicated genes unequally during evolution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping