ZFIN ID: ZDB-PUB-031217-2
Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome
Cortés, F., Daggett, D., Bryson-Richardson, R.J., Neyt, C., Maule, J., Gautier, P., Hollway, G.E., Keenan, D., and Currie, P.D.
Date: 2003
Source: Developmental Cell   5(6): 865-876 (Journal)
Registered Authors: Bryson-Richardson, Robert, Currie, Peter D., Daggett, Dave, Maule, John, Neyt, Christine
Keywords: none
MeSH Terms:
  • Animals
  • Cadherins/genetics*
  • Cadherins/metabolism
  • Cell Adhesion/physiology
  • Cell Movement/physiology*
  • Gene Expression Regulation, Developmental
  • Muscle Fibers, Slow-Twitch/cytology*
  • Muscle Fibers, Slow-Twitch/physiology*
  • Muscle, Skeletal/cytology*
  • Muscle, Skeletal/embryology*
  • Muscle, Skeletal/physiology
  • Mutagenesis, Site-Directed
  • Zebrafish
PubMed: 14667409 Full text @ Dev. Cell
Differential cell adhesion has long been postulated to play important roles in cell sorting and cell migration; however, these roles have been studied in very few specific contexts. Thus, the deployment and utility of differential adhesion as a developmental mechanism remains somewhat unclear. Cortes et al. find that a dynamic wave of characteristic cadherin expression moves through the developing somite, and is required to guide adaxial (presumptive slow twitch) muscle cells across the entire width of the myotome. This work establishes important principles underlying the contribution of differential cell adhesion to vertebrate morphogenesis.