PUBLICATION

Fishing for novel angiogenic therapies

Authors
Kidd, K.R. and Weinstein, B.M.
ID
ZDB-PUB-031014-9
Date
2003
Source
British journal of pharmacology   140(4): 585-594 (Review)
Registered Authors
Kidd, Kameha, Weinstein, Brant M.
Keywords
none
MeSH Terms
  • Angiogenesis Inducing Agents/therapeutic use*
  • Animals
  • Blood Vessels/embryology
  • Drug Design*
  • Drug Evaluation, Preclinical
  • Models, Animal*
  • Zebrafish/anatomy & histology
  • Zebrafish/physiology
PubMed
14534143 Full text @ Br. J. Pharmacol.
Abstract
The zebrafish has recently emerged as an important model for the study of vascular embryogenesis. Its genetic accessibility, external development, and optically clear embryo are just a few of the features that set the zebrafish apart as a particularly well-suited model for studying vascular development. However, there is little precedent for its use as a tool for the experimental study of therapeutic angiogenesis. Here, we review the use of the zebrafish for studying vascular development and patterning, and discuss how the zebrafish might be used more directly as a model for developing and testing effective therapeutic angiogenesis approaches.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes