PUBLICATION

The zebrafish as a model for muscular dystrophy and congenital myopathy

Authors
Bassett, D.I. and Currie, P.D.
ID
ZDB-PUB-031001-11
Date
2003
Source
Human molecular genetics   (Suppl. 2) 12: R265-R270 (Review)
Registered Authors
Bassett, David, Currie, Peter D.
Keywords
none
MeSH Terms
  • Animals
  • Disease Models, Animal*
  • Humans
  • Mice
  • Muscular Diseases/congenital
  • Muscular Diseases/genetics*
  • Muscular Dystrophies/genetics*
  • Zebrafish
PubMed
14504264 Full text @ Hum. Mol. Genet.
Abstract
The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal muscle, which lead to a loss of muscle function and are often fatal. While many of the loci involved are already known, these conditions remain incurable, and genetic models are being developed in an effort to understand the pathological mechanisms involved. Recently several papers have shown that the zebrafish, which is now widely used in developmental genetic studies, will provide a useful addition to our toolkit in this regard. Here we describe these studies, including a zebrafish model of what is potentially the novel pathological mechanism of muscle attachment failure in Duchenne and other muscular dystrophies.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping