lunatic fringe regulates delta-notch induction of hypochord in zebrafish
- Appel, B., Marasco, P., McClung, L.E., and Latimer, A.J.
- Developmental Dynamics : an official publication of the American Association of Anatomists 228(2): 281-286 (Journal)
- Registered Authors
- Appel, Bruce, Latimer, Andrew
- MeSH Terms
- Body Patterning
- Cloning, Molecular
- Gene Expression Regulation, Developmental/drug effects*
- In Situ Hybridization
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins/genetics
- Membrane Proteins/metabolism*
- Oligonucleotides, Antisense/pharmacology
- Receptors, Notch
- Signal Transduction
- Zebrafish Proteins/physiology
- 14518000 Full text @ Dev. Dyn.
Appel, B., Marasco, P., McClung, L.E., and Latimer, A.J. (2003) lunatic fringe regulates delta-notch induction of hypochord in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(2):281-286.
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes