PUBLICATION

Ringing in the new ear: resolution of cell interactions in otic development

Authors
Riley, B.B. and Phillips, B.T.
ID
ZDB-PUB-030929-1
Date
2003
Source
Developmental Biology   261(2): 289-312 (Journal)
Registered Authors
Riley, Bruce
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning/physiology
  • Cell Differentiation/physiology
  • Chick Embryo
  • DNA-Binding Proteins/metabolism
  • Ear, Inner/embryology*
  • Embryonic Induction/physiology*
  • Epithelium/embryology
  • Gene Expression Regulation, Developmental
  • Humans
  • Mice
  • Transcription Factors/metabolism
PubMed
14499642 Full text @ Dev. Biol.
Abstract
The vertebrate inner ear is a marvel of structural and functional complexity, which is all the more remarkable because it develops from such a simple structure, the otic placode. Analysis of inner ear development has long been a fascination of experimental embryologists, who sought to understand cellular mechanisms of otic placode induction. More recently, however, molecular and genetic approaches have made the inner ear a useful model system for studying a much broader range of basic developmental mechanisms, including cell fate specification and differentiation, axial patterning, epithelial morphogenesis, cytoskeletal dynamics, stem cell biology, neurobiology, physiology, etc. Of course, there has also been tremendous progress in understanding the functions and processes peculiar to the inner ear. The goal of this review is to recount how historical approaches have shaped our understanding of the signaling interactions controlling early otic development; to discuss how new findings have led to fundamental new insights; and to point out new problems that need to be resolved in future research.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes