PUBLICATION
Chemical genetics: adding to the developmental biology toolbox
- Authors
- Yeh, J.-R. and Crews, C.M.
- ID
- ZDB-PUB-030910-5
- Date
- 2003
- Source
- Developmental Cell 5(1): 11-19 (Review)
- Registered Authors
- Yeh, Jing-Ruey (Joanna)
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation
- Developmental Biology*
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental/drug effects*
- Humans
- Models, Biological
- Molecular Biology*
- Mutation
- Signal Transduction
- Teratogens/toxicity
- Vertebrates/embryology
- Vertebrates/genetics
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism
- PubMed
- 12852848 Full text @ Dev. Cell
Citation
Yeh, J.-R. and Crews, C.M. (2003) Chemical genetics: adding to the developmental biology toolbox. Developmental Cell. 5(1):11-19.
Abstract
Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping