PUBLICATION
When Wnts antagonize Wnts
- Authors
- Weidinger, G. and Moon, R.T.
- ID
- ZDB-PUB-030908-7
- Date
- 2003
- Source
- The Journal of cell biology 162(5): 753-756 (Review)
- Registered Authors
- Moon, Randall T., Weidinger, Gilbert
- Keywords
- none
- MeSH Terms
-
- Animals
- Cytoskeletal Proteins/metabolism
- Mice
- Morphogenesis/physiology
- Proto-Oncogene Proteins/genetics
- Proto-Oncogene Proteins/metabolism*
- Signal Transduction/physiology*
- Trans-Activators/metabolism
- Wnt Proteins
- Zebrafish/embryology
- Zebrafish Proteins*
- beta Catenin
- PubMed
- 12952929 Full text @ J. Cell Biol.
Citation
Weidinger, G. and Moon, R.T. (2003) When Wnts antagonize Wnts. The Journal of cell biology. 162(5):753-756.
Abstract
Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/beta-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of beta-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/beta-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping