PUBLICATION
The evolutionary relationships of zebrafish genes tbx6, tbx16/ spadetail and mga
- Authors
- Lardelli, M.
- ID
- ZDB-PUB-030812-3
- Date
- 2003
- Source
- Development genes and evolution 213(10): 519-522 (Journal)
- Registered Authors
- Lardelli, Michael
- Keywords
- T-box genes, Zebrafish, Evolution, Genome
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary/genetics
- Humans
- Molecular Sequence Data
- Phylogeny*
- Sequence Alignment
- Sequence Analysis, DNA
- T-Box Domain Proteins/genetics*
- Transcription Factors/genetics*
- Zebrafish/genetics*
- Zebrafish Proteins/genetics*
- PubMed
- 12908107 Full text @ Dev. Genes Evol.
Citation
Lardelli, M. (2003) The evolutionary relationships of zebrafish genes tbx6, tbx16/ spadetail and mga. Development genes and evolution. 213(10):519-522.
Abstract
The T-box (Tbx) genes encode a family of transcription factors required for development of vertebrate embryos. In an attempt to discover human orthologues of the zebrafish ( Danio rerio) tbx6 and tbx16/ spadetail genes, we found that the most similar human ( Homo sapiens) gene is the orthologue of mouse ( Mus musculus) Mga ( MAX gene associated). We have identified the zebrafish orthologue of Mga using analyses of sequence similarity and the orthologies of syntenic genes. Zebrafish mga maps close to dtk ( developmental receptor tyrosine kinase), the orthologue of human TYRO3 ( TYRO3 protein tyrosine kinase). Like its human and mouse orthologues, zebrafish mga lacks the three conserved introns within the T-box coding sequences that are characteristic of the vertebrate T-box gene family. This suggests that these genes are derived from an ancient reverse transcription event. The human genome does not appear to possess orthologues of zebrafish tbx6 or tbx16/ spadetail.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping