PUBLICATION
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
- Authors
- Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A., and Grunwald, D.J.
- ID
- ZDB-PUB-030730-12
- Date
- 2003
- Source
- Proceedings of the National Academy of Sciences of the United States of America 100(16): 9410-9415 (Journal)
- Registered Authors
- Bisgrove, Brent, Goering, Lisa, Grunwald, David, Hoshijima, Kazuyuki, Hug, Barbara
- Keywords
- none
- MeSH Terms
-
- Animals
- Base Sequence
- Fetal Proteins
- Gene Expression Regulation, Developmental*
- Genotype
- Humans
- Mesoderm/metabolism*
- Models, Biological
- Models, Genetic
- Molecular Sequence Data
- MyoD Protein/metabolism
- Plasmids/metabolism
- T-Box Domain Proteins/genetics*
- T-Box Domain Proteins/metabolism
- T-Box Domain Proteins/physiology*
- Transcriptional Activation
- Zebrafish
- Zebrafish Proteins/metabolism
- PubMed
- 12883008 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A., and Grunwald, D.J. (2003) An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proceedings of the National Academy of Sciences of the United States of America. 100(16):9410-9415.
Abstract
T-box genes encode transcription factors that play critical roles in generating the vertebrate body plan. In many developmental fields, multiple T-box genes are expressed in overlapping domains, establishing broad regions in which different combinations of T-box genes are coexpressed. Here we demonstrate that three T-box genes expressed in the zebrafish mesoderm, no tail, spadetail, and tbx6, operate as a network of interacting genes to regulate region-specific gene expression and developmental fate. Loss-of-function and gain-of-function genetic analyses reveal three kinds of interactions among the T-box genes: combinatorial interactions that generate new regulatory functions, additive contributions to common developmental pathways, and competitive antagonism governing downstream gene expression. We propose that T-box genes, like Hox genes, often function within gene networks comprised of related family members.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping