PUBLICATION
Cadherin expression in the inner ear of developing zebrafish
- Authors
- Novince, Z.M., Azodi, E., Marrs, J.A., Raymond, P.A., and Liu, Q.
- ID
- ZDB-PUB-030716-16
- Date
- 2003
- Source
- Gene expression patterns : GEP 3(3): 337-339 (Journal)
- Registered Authors
- Liu, Qin, Marrs, James A., Raymond, Pamela
- Keywords
- none
- MeSH Terms
-
- Animals
- Cadherins/biosynthesis
- Cadherins/genetics*
- Ear, Inner/embryology
- Ear, Inner/metabolism*
- Gene Expression Profiling
- In Situ Hybridization
- RNA, Messenger/metabolism
- Zebrafish/embryology
- Zebrafish/metabolism*
- PubMed
- 12799081 Full text @ Gene Expr. Patterns
Citation
Novince, Z.M., Azodi, E., Marrs, J.A., Raymond, P.A., and Liu, Q. (2003) Cadherin expression in the inner ear of developing zebrafish. Gene expression patterns : GEP. 3(3):337-339.
Abstract
Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping