ZFIN ID: ZDB-PUB-030716-15
Sequence and embryonic expression of collagen XVIII NC1 domain (endostatin) in the zebrafish
Haftek, Z., Morvan-Dubois, G., Thisse, B., Thisse, C., Garrone, R., and Le Guellec, D.
Date: 2003
Source: Gene expression patterns : GEP   3(3): 351-354 (Journal)
Registered Authors: Le Guellec, Dominique, Thisse, Bernard, Thisse, Christine
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Endostatins/biosynthesis
  • Endostatins/genetics*
  • In Situ Hybridization
  • Molecular Sequence Data
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed: 12799084 Full text @ Gene Expr. Patterns
Endostatin, located in the NC1 domain of the collagen XVIII, is believed to inhibit the migration and proliferation of endothelial cells (Fed. Am. Soc. Exp. Biol. J. 15 (2001) 1044) and to play a role in axon guidance in Caenorhabditis elegans (J. Cell Biol. 152 (2001) 1219). Zebrafish is an attractive vertebrate model to determine the role of endostatin and the entire molecule of collagen XVIII during vertebrate development. Therefore, we have investigated the expression pattern of COL18A1 in zebrafish embryos from the segmentation to the hatching period stages.