PUBLICATION
A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
- Authors
- Oertle, T., Klinger, M., Stürmer, C.A., and Schwab, M.E.
- ID
- ZDB-PUB-030714-1
- Date
- 2003
- Source
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17(10): 1238-1247 (Journal)
- Registered Authors
- Klinger, Michael, Stuermer, Claudia
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans/genetics
- Carrier Proteins*
- Conserved Sequence
- Evolution, Molecular*
- Exons
- Fungi/genetics
- Humans
- Insecta/genetics
- Intracellular Signaling Peptides and Proteins*
- Introns
- Membrane Proteins/classification*
- Membrane Proteins/genetics*
- Molecular Sequence Data
- Myelin Proteins/classification
- Myelin Proteins/genetics
- Nerve Tissue Proteins/classification
- Nerve Tissue Proteins/genetics
- Phylogeny*
- Plants/genetics
- Schistosoma mansoni/genetics
- Terminology as Topic*
- Vertebrates/genetics
- PubMed
- 12832288 Full text @ FASEB J.
Citation
Oertle, T., Klinger, M., Stürmer, C.A., and Schwab, M.E. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(10):1238-1247.
Abstract
Reticulon (RTN) genes code for a family of proteins relatively recently described in higher vertebrates. The four known mammalian paralogues (RTN1, -2, -3, and -4/Nogo) have homologous carboxyl termini with two characteristic large hydrophobic regions. Except for RTN4-A/Nogo-A, thought to be an inhibitor for neurite outgrowth, restricting the regenerative capabilities of the mammalian CNS after injury, the functions of other family members are largely unknown. The overall occurrence of RTNs in different phyla and the evolution of the RTN gene family have hitherto not been analyzed. Here we expound data showing that the RTN family has arisen during early eukaryotic evolution potentially concerted to the establishment of the endomembrane system. Over 250 reticulon-like (RTNL) genes were identified in deeply diverging eukaryotes, fungi, plants, and animals. A systematic nomenclature for all identified family members is introduced. The analysis of exon-intron arrangements and of protein homologies allowed us to isolate key steps in the history of these genes. Our data corroborate the hypothesis that present RTNs evolved from an intron-rich reticulon ancestor mainly by the loss of different introns in diverse phyla. We also present evidence that the exceptionally large RTN4-A-specific exon 3, which harbors a potent neurite growth inhibitory region, may have arisen de novo approximately 350 MYA during transition to land vertebrates. These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping