PUBLICATION

Opinion: Cancer genetics and drug discovery in the zebrafish

Authors
Stern, H.M. and Zon, L.I.
ID
ZDB-PUB-030707-9
Date
2003
Source
Nature reviews. Cancer   3(7): 533-539 (Review)
Registered Authors
Stern, Howard, Zon, Leonard I.
Keywords
none
MeSH Terms
  • Animals
  • Antineoplastic Agents/therapeutic use*
  • Drug Evaluation/methods
  • Neoplasms/drug therapy*
  • Neoplasms/genetics*
  • Zebrafish/genetics*
PubMed
12835673 Full text @ Nat. Rev. Cancer
Abstract
Fish have a long history of use in cancer toxicology studies, because they develop neoplasms that are histologically similar to human cancers. Because of considerable progress in zebrafish genetics and genomics over the past few years, the zebrafish system has provided many useful tools for studying basic biological processes. These tools include forward genetic screens, transgenic models, specific gene disruptions and small-molecule screens. By combining carcinogenesis assays, genetic analyses and small-molecule screening techniques, the zebrafish is emerging as a powerful system for identifying novel cancer genes and for cancer drug discovery.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping