PUBLICATION
Nuclear receptors are markers of animal genome evolution
- Authors
- Escriva Garcia, H., Laudet, V., and Robinson-Rechavi, M.
- ID
- ZDB-PUB-030707-7
- Date
- 2003
- Source
- Journal of structural and functional genomics 3(1-4): 177-184 (Review)
- Registered Authors
- Escriva, Hector, Laudet, Vincent, Robinson-Rechavi, Marc
- Keywords
- none
- MeSH Terms
-
- Animals
- Evolution, Molecular*
- Gene Duplication
- Genetic Markers
- Genome*
- Phylogeny
- Receptors, Cytoplasmic and Nuclear/genetics*
- PubMed
- 12836696 Full text @ J. Struct. Funct. Genom.
Citation
Escriva Garcia, H., Laudet, V., and Robinson-Rechavi, M. (2003) Nuclear receptors are markers of animal genome evolution. Journal of structural and functional genomics. 3(1-4):177-184.
Abstract
Nuclear hormone receptors form one evolutionary related super-family of proteins, which mediate the interaction between hormones (or other ligands) and gene expression in animals. Early phylogenetic analyses showed two main periods of gene duplication which gave rise to present-day diversity in most animals: one at the origin of the family, and another specifically in vertebrates. Moreover this second period is composed itself by, probably, two rounds of duplication, as proposed by Susumu Ohno at the origin of vertebrates. There are indeed often two, three or four vertebrate orthologs of each invertebrate nuclear receptor, in accordance with this theory. The complete genome of Drosophila melanogaster contains 21 nuclear receptors, compared to 49 in the human genome. In addition, many nuclear receptors have more paralogs in the zebrafish than in mammals, and a genome duplication has been proposed at the origin of ray-finned fishes. Nuclear receptors are a very good model to investigate the dating and functional role of these duplications, since they are dispersed in the genome, allow robust phylogenetic reconstruction, and are functionnaly well characterized, with different adaptations for different paralogs. We illustrate this with examples from differents nuclear receptors and different groups of species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping