ZFIN ID: ZDB-PUB-030707-4
Making a zebrafish kidney: a tale of two tubes
Drummond, I.
Date: 2003
Source: Trends in cell biology   13(7): 357-365 (Journal)
Registered Authors: Drummond, Iain
Keywords: none
MeSH Terms:
  • Animals
  • Cell Communication/physiology
  • Cell Differentiation/physiology*
  • Cell Size/physiology
  • Epithelial Cells/metabolism*
  • Epithelial Cells/ultrastructure
  • Humans
  • Kidney Diseases, Cystic/etiology
  • Kidney Diseases, Cystic/pathology
  • Kidney Diseases, Cystic/physiopathology
  • Kidney Tubules/blood supply*
  • Kidney Tubules/embryology*
  • Kidney Tubules/ultrastructure
  • Renal Artery/embryology*
  • Renal Artery/ultrastructure
  • Renal Circulation/physiology
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed: 12837606 Full text @ Trends Cell Biol.
The kidney can be thought of as the pairing of two tubes: an epithelial tube (the nephron), carrying filtered blood and engaged in ion and water transport; and endothelial tubes (the blood vessels), delivering blood and carrying away recovered solute. The development of the nephron presents several interesting questions. How does an epithelial tube form and how is it patterned into functionally distinct components and segments? What guides the interaction between the vasculature and kidney epithelia? How are epithelial cell shape and lumen diameter maintained, and what goes wrong when kidney tubules balloon into cysts? Here, I outline the progress that has been made in answering these questions using the zebrafish pronephros as a simple, accessible model of nephron development.