Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
- Malicki, J., Jo, H., and Pujic, Z.
- Developmental Biology 259(1): 95-108 (Journal)
- Registered Authors
- Jo, Hakryul, Malicki, Jarema, Pujic, Zac
- MeSH Terms
- Amino Acid Sequence
- Body Patterning
- Chromosome Mapping
- Molecular Sequence Data
- 12812791 Full text @ Dev. Biol.
Malicki, J., Jo, H., and Pujic, Z. (2003) Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning. Developmental Biology. 259(1):95-108.
Genetic screens in zebrafish identified several loci that play essential roles in the patterning of retinal architecture. Here, we show that one of them, glass onion, encodes the N-cadherin gene. The glo(m117) mutant allele contains a substitution of the Trp2 residue known for its essential role in the adhesive properties of classic cadherins. Both the glo(m117) and pac(tm101b) mutant N-cadherin alleles affect the polarity of the retinal neuroepithelial sheet and, unexpectedly, both result in cell-nonautonomous phenotypes in retinal patterning. The late onset of mutant N-cadherin phenotypes may be due to the ability of classic cadherins to substitute each other's function.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes