PUBLICATION
Identification and developmental expression of a macrophage stimulating 1/ hepatocyte growth factor-like 1 orthologue in the zebrafish
- Authors
- Bassett, D.I.
- ID
- ZDB-PUB-030527-2
- Date
- 2003
- Source
- Development genes and evolution 213(7): 360-362 (Journal)
- Registered Authors
- Bassett, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Embryo, Nonmammalian/embryology
- Gene Expression Regulation, Developmental
- Hepatocyte Growth Factor/analysis
- Hepatocyte Growth Factor/genetics*
- Morphogenesis
- Proto-Oncogene Proteins/analysis
- Proto-Oncogene Proteins/genetics*
- Receptor Protein-Tyrosine Kinases/genetics
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 12764615 Full text @ Dev. Genes Evol.
Citation
Bassett, D.I. (2003) Identification and developmental expression of a macrophage stimulating 1/ hepatocyte growth factor-like 1 orthologue in the zebrafish. Development genes and evolution. 213(7):360-362.
Abstract
The cytokine Macrophage Stimulating 1 (MST1/MSP/Hepatocyte Growth Factor-Like) is a ligand of the Met-related MST1-Receptor (MST1R/RON). Although MST1-deficient mice are viable, MST1R is essential in mice before gastrulation for implantation, and is a known oncogene in man. Here I report the identification, sequence, chromosomal location and embryonic expression of a novel zebrafish orthologue, termed macrophage stimulating 1 ( mst1). mst1 shows a striking restriction of expression to the dorsal side of the embryo prior to gastrulation, and as gastrulation and somitogenesis proceed is expressed sequentially in the presumptive neurectoderm, the notochord, the somites, endodermal cells and in the syncytial yolk. This dynamic pattern is largely conserved in tetrapod vertebrates, suggesting that the appearance of MST1, may have played an early role in the evolution of the vertebrate body plan.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping