PUBLICATION

Gonadotropin-releasing hormone (gnrh) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio

Authors
Whitlock, K.E., Wolf, C.D., and Boyce, M.L.
ID
ZDB-PUB-030514-3
Date
2003
Source
Developmental Biology   257(1): 140-152 (Journal)
Registered Authors
Boyce, Mayely, Whitlock, Kate, Wolf, Catherine
Keywords
none
MeSH Terms
  • Neural Crest/metabolism*
  • Immunohistochemistry
  • Gonadotropin-Releasing Hormone/metabolism*
  • Mutation
  • Carbocyanines
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zebrafish/embryology*
  • Transcription Factors/genetics
  • Transcription Factors/metabolism
  • Staining and Labeling
  • Head/embryology
  • Animals
  • Pituitary Gland, Anterior/embryology
  • Pituitary Gland, Anterior/metabolism
(all 15)
PubMed
12710963 Full text @ Dev. Biol.
Abstract
The olfactory placodes generate the primary sensory neurons of the olfactory sensory system. Additionally, the olfactory placodes have been proposed to generate a class of neuroendocrine cells containing gonadotropin-releasing hormone (GnRH). GnRH is a multifunctional decapeptide essential for the development of secondary sex characteristics in vertebrates as well as a neuromodulator within the central nervous system. Here, we show that endocrine and neuromodulatory GnRH cells arise from two separate, nonolfactory regions in the developing neural plate. Specifically, the neuromodulatory GnRH cells of the terminal nerve arise from the cranial neural crest, and the endocrine GnRH cells of the hypothalamus arise from the adenohypophyseal region of the developing anterior neural plate. Our findings are consistent with cell types generated by the adenohypophysis, a source of endocrine tissue in vertebrate animals, and by neural crest, a source of cells contributing to the cranial nerves. The adenohypophysis arises from a region of the anterior neural plate flanked by the olfactory placode fields at early stages of development, and premigratory cranial neural crest lies adjacent to the caudal edge of the olfactory placode domain [Development 127 (2000), 3645]. Thus, the GnRH cells arise from tissue closely associated with the developing olfactory placode, and their different developmental origins reflect their different functional roles in the adult animal.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
gli1_unspecified
    		Unspecified
    gli2a_unspecified
      		Unspecified
      1 - 2 of 2
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      Fish
      gli1unspecified/unspecified
      gli2aunspecified/unspecified
      1 - 2 of 2
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      Antibodies
      Name Type Antigen Genes Isotypes Host Organism
      Ab1-gnrh3monoclonalMouse
      1 - 1 of 1
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      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
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      Citation
      Whitlock, K.E., Wolf, C.D., and Boyce, M.L. (2003) Gonadotropin-releasing hormone (gnrh) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio. Developmental Biology. 257(1):140-152.