PUBLICATION
Zebrafish: from disease modeling to drug discovery
- Authors
- Rubinstein, A.L.
- ID
- ZDB-PUB-030408-9
- Date
- 2003
- Source
- Curr. Opin. Drug Discov. Devel. 6(2): 218-223 (Review)
- Registered Authors
- Rubinstein, Amy
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Humans
- Pharmacology/trends*
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 12669457
Citation
Rubinstein, A.L. (2003) Zebrafish: from disease modeling to drug discovery. Curr. Opin. Drug Discov. Devel.. 6(2):218-223.
Abstract
The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. This review summarizes recent progress in disease model development, and outlines the potential of zebrafish to contribute to drug discovery through the identification of novel drug targets, validation of those targets and screening for new therapeutic compounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping