PUBLICATION
The transformation of the model organism: a decade of developmental genetics
- Authors
- Anderson, K.V. and Ingham, P.W.
- ID
- ZDB-PUB-030304-1
- Date
- 2003
- Source
- Nature Genetics (Suppl.) 33: 285-293 (Review)
- Registered Authors
- Ingham, Philip
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Polarity
- Developmental Biology/history
- Developmental Biology/trends
- Drosophila/genetics
- Drosophila/growth & development
- Feedback
- Genetics/history
- Genetics/trends
- History, 20th Century
- History, 21st Century
- Humans
- Mice
- Models, Genetic*
- Signal Transduction
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 12610538 Full text @ Nat. Genet.
Citation
Anderson, K.V. and Ingham, P.W. (2003) The transformation of the model organism: a decade of developmental genetics. Nature Genetics. (Suppl.) 33:285-293.
Abstract
The past decade has seen the development of powerful techniques to dissect the molecular processes that regulate development. New tools have been used to reveal the basis of cell polarity, morphogen gradients and regulation of signaling in developing animals. Cell biology and developmental biology have become closely intertwined, and many genes that had been thought of as regulators of general cell biological (housekeeping) functions have been shown to act as specific developmental regulators. Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping