ZFIN ID: ZDB-PUB-030211-3
Tales of regeneration in zebrafish
Poss, K.D., Keating, M.T., and Nechiporuk, A.
Date: 2003
Source: Developmental dynamics : an official publication of the American Association of Anatomists   226(2): 202-210 (Review)
Registered Authors: Keating, Mark T., Nechiporuk, Alex, Poss, Kenneth D.
Keywords: zebrafish, wound healing, regeneration, fin, limb, blastema, fgf, Shh
MeSH Terms:
  • Animals
  • Regeneration/physiology*
  • Wound Healing/physiology
  • Zebrafish/physiology*
PubMed: 12557199 Full text @ Dev. Dyn.
Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. To address this deficiency, we and others have focused on the zebrafish model system. Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins.