PUBLICATION

Old questions, new tools, and some answers to the mystery of fin regeneration

Authors

Akimenko, M.-A., Marí-Beffa, M., Becerra, J., and Géraudie, J.

ID

ZDB-PUB-030211-2

Date

2003

Source

Developmental Dynamics : an official publication of the American Association of Anatomists 226(2): 190-201 (Journal)

Registered Authors

Akimenko, Marie-Andree, Géraudie, Jacqueline, Marí-Beffa, Manuel

Keywords

bony rays, fin, regeneration, teleosts, zebrafish

MeSH Terms

Amputation, Traumatic
Animals
Fishes/physiology*
Nervous System Physiological Phenomena
Regeneration/physiology*
Skin Physiological Phenomena

PubMed

12557198 Full text @ Dev. Dyn.

Abstract

Pluridisciplinary approaches led to the notion that fin regeneration is an intricate phenomenon involving epithelial-mesenchymal and reciprocal exchanges throughout the process as well as interactions between ray and interray tissue. The establishment of a blastema after fin amputation is the first event leading to the reconstruction of the missing part of the fin. Here, we review our knowledge on the origin of the blastema, its formation and growth, and of the mechanisms that control differentiation and patterning of the regenerate. Our current understanding results from studies of fin regeneration performed in various teleost fish over the past century. We also report the recent breakthroughs that have been made in the past decade with the arrival of a new model, the zebrafish, Danio rerio, which now offers the possibility to combine cytologic, molecular, and genetic analyses and open new perspectives in this field.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Akimenko et al., 2003 ZDB-PUB-030211-2 PMID:12557198

Old questions, new tools, and some answers to the mystery of fin regeneration

Akimenko et al., 2003

ZDB-PUB-030211-2
PMID:12557198