PUBLICATION

The parapineal mediates left-right asymmetry in the zebrafish diencephalon

Authors
Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E.
ID
ZDB-PUB-030206-1
Date
2003
Source
Development (Cambridge, England)   130: 1059-1068 (Journal)
Registered Authors
Gamse, Josh, Halpern, Marnie E., Thisse, Bernard, Thisse, Christine
Keywords
none
MeSH Terms
  • Animals
  • Cation Transport Proteins
  • Diencephalon/embryology*
  • Diencephalon/growth & development*
  • Embryonic Induction/physiology*
  • Nerve Tissue Proteins/genetics*
  • Nerve Tissue Proteins/metabolism
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed
12571098 Full text @ Development
Abstract
The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ - the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes