The parapineal mediates left-right asymmetry in the zebrafish diencephalon
- Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E.
- Development (Cambridge, England) 130: 1059-1068 (Journal)
- Registered Authors
- Gamse, Josh, Halpern, Marnie E., Thisse, Bernard, Thisse, Christine
- MeSH Terms
- Cation Transport Proteins
- Diencephalon/growth & development*
- Embryonic Induction/physiology*
- Nerve Tissue Proteins/genetics*
- Nerve Tissue Proteins/metabolism
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- 12571098 Full text @ Development
Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E. (2003) The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development (Cambridge, England). 130:1059-1068.
The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ - the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes