ZFIN ID: ZDB-PUB-030206-1
The parapineal mediates left-right asymmetry in the zebrafish diencephalon
Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E.
Date: 2003
Source: Development (Cambridge, England)   130: 1059-1068 (Journal)
Registered Authors: Gamse, Josh, Halpern, Marnie E., Thisse, Bernard, Thisse, Christine
Keywords: none
MeSH Terms:
  • Animals
  • Cation Transport Proteins
  • Diencephalon/embryology*
  • Diencephalon/growth & development*
  • Embryonic Induction/physiology*
  • Nerve Tissue Proteins/genetics*
  • Nerve Tissue Proteins/metabolism
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed: 12571098 Full text @ Development
The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ - the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.