PUBLICATION
Catching a wave: the oscillator and wavefront that create the zebrafish somite
- Authors
- Holley, S.A. and Takeda, H.
- ID
- ZDB-PUB-030117-1
- Date
- 2002
- Source
- Seminars in cell & developmental biology 13(6): 481-486 (Review)
- Registered Authors
- Holley, Scott, Takeda, Hiroyuki
- Keywords
- her; delta; notch; fgf; fss/tbx24
- MeSH Terms
-
- Animals
- Biological Clocks
- Embryonic and Fetal Development/genetics
- Signal Transduction/genetics
- Somites/cytology
- Somites/physiology*
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 12468251 Full text @ Sem. Cell Dev. Biol.
Citation
Holley, S.A. and Takeda, H. (2002) Catching a wave: the oscillator and wavefront that create the zebrafish somite. Seminars in cell & developmental biology. 13(6):481-486.
Abstract
Segmentation of the paraxial mesoderm is governed by an oscillator mechanism that creates a dynamic prepattern within the caudal presomitic mesoderm. The oscillator is comprised of genetic circuit involving the Notch signaling pathway and its target genes her1 and her7. The stabilization of the oscillating prepattern is antagonized by a gradient of Fgf signaling which is highest in the caudal presomitic mesoderm. Once the level of Fgf signaling declines in the rostral presomitic mesoderm, a wavefront mediated by the transcription factor fss/tbx24, stabilizes the prepattern and leads to the segmental expression of a number of genes which then establish segment polarity and initiate morphological somite formation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping