PUBLICATION
Making the connection: retinal axon guidance in the zebrafish
- Authors
- Culverwell, J. and Karlstrom, R.O.
- ID
- ZDB-PUB-030116-9
- Date
- 2002
- Source
- Seminars in cell & developmental biology 13(6): 497-506 (Journal)
- Registered Authors
- Karlstrom, Rolf
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology*
- Embryonic and Fetal Development/genetics
- Mutation
- Prosencephalon/embryology
- Retina/embryology*
- Retina/growth & development
- Zebrafish/embryology*
- PubMed
- 12468253 Full text @ Sem. Cell Dev. Biol.
Citation
Culverwell, J. and Karlstrom, R.O. (2002) Making the connection: retinal axon guidance in the zebrafish. Seminars in cell & developmental biology. 13(6):497-506.
Abstract
Genetic screens in zebrafish have identified a large number of mutations that affect neural connectivity in the developing visual system. These mutants define genes essential for accurate retinal axon guidance in the eye and brain and the characterization of these mutants is helping to define the cellular and molecular mechanisms that guide axons in the vertebrate embryo. The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping