ZFIN ID: ZDB-PUB-030116-9
Making the connection: retinal axon guidance in the zebrafish
Culverwell, J. and Karlstrom, R.O.
Date: 2002
Source: Seminars in cell & developmental biology   13(6): 497-506 (Journal)
Registered Authors: Karlstrom, Rolf
Keywords: none
MeSH Terms:
  • Animals
  • Axons/physiology*
  • Embryonic and Fetal Development/genetics
  • Mutation
  • Prosencephalon/embryology
  • Retina/embryology*
  • Retina/growth & development
  • Zebrafish/embryology*
PubMed: 12468253 Full text @ Sem. Cell Dev. Biol.
Genetic screens in zebrafish have identified a large number of mutations that affect neural connectivity in the developing visual system. These mutants define genes essential for accurate retinal axon guidance in the eye and brain and the characterization of these mutants is helping to define the cellular and molecular mechanisms that guide axons in the vertebrate embryo. The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain.