PUBLICATION
Zebrafish gastrulation movements: bridging cell and developmental biology
- Authors
- Heisenberg, C.-P. and Tada, M.
- ID
- ZDB-PUB-030116-2
- Date
- 2002
- Source
- Seminars in cell & developmental biology 13(6): 471-479 (Review)
- Registered Authors
- Heisenberg, Carl-Philipp, Tada, Masazumi
- Keywords
- gastrulation; convergent extension; cell polarity; zebrafish
- MeSH Terms
-
- Animals
- Cell Movement/genetics
- Embryonic and Fetal Development/genetics*
- Gastrula/cytology*
- Mutation
- Signal Transduction
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 12468250 Full text @ Sem. Cell Dev. Biol.
Citation
Heisenberg, C.-P. and Tada, M. (2002) Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in cell & developmental biology. 13(6):471-479.
Abstract
During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping