PUBLICATION
EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1
- Authors
- Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., and Schier, A.F.
- ID
- ZDB-PUB-030115-13
- Date
- 2003
- Source
- Genes & Development 17(1): 31-36 (Journal)
- Registered Authors
- Bennett, Jimmy, Olale, Felix, Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Activin Receptors, Type I/genetics
- Activin Receptors, Type I/physiology
- Activin Receptors, Type II/physiology*
- Animals
- Bone Morphogenetic Protein Receptors, Type I
- Bone Morphogenetic Proteins/physiology*
- Epidermal Growth Factor*
- GPI-Linked Proteins
- Glycoproteins/physiology*
- Growth Differentiation Factors
- Homeodomain Proteins/genetics
- Homeodomain Proteins/physiology*
- Intercellular Signaling Peptides and Proteins
- Macromolecular Substances
- Membrane Glycoproteins*
- Mice
- Neoplasm Proteins/physiology
- Nodal Protein
- Protein Serine-Threonine Kinases*
- Proteins*
- Receptors, Growth Factor*
- Receptors, Transforming Growth Factor beta/genetics
- Receptors, Transforming Growth Factor beta/physiology
- Recombinant Fusion Proteins/physiology
- Signal Transduction/physiology
- Species Specificity
- Transcription Factors/deficiency
- Transcription Factors/genetics
- Transcription Factors/physiology*
- Transforming Growth Factor beta/physiology*
- Xenopus Proteins*
- Xenopus laevis/embryology
- Zebrafish
- Zebrafish Proteins*
- PubMed
- 12514096 Full text @ Genes & Dev.
Citation
Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., and Schier, A.F. (2003) EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. Genes & Development. 17(1):31-36.
Abstract
The TGF-beta signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping