ZFIN ID: ZDB-PUB-030115-10
The zebrafish as a tool for understanding the biology of visual disorders
Goldsmith, P. and Harris, W.A.
Date: 2003
Source: Seminars in cell & developmental biology   14(1): 11-18 (Review)
Registered Authors: Harris, William A.
Keywords: Disease; Retina; Retinal; Vision; Zebrafish
MeSH Terms:
  • Animals
  • Blindness/etiology
  • Clinical Laboratory Techniques
  • Models, Animal
  • Retina/anatomy & histology
  • Retina/pathology
  • Retinal Degeneration/etiology
  • Vision Disorders/etiology*
  • Vision Disorders/genetics
  • Vision Disorders/pathology
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed: 12524002 Full text @ Sem. Cell Dev. Biol.
Retinal degenerations are the commonest cause of blindness in the Western world, affecting 5% of the population, yet remain largely untreatable. A better understanding of the mechanisms of disease is needed. Zebrafish fill a gap in the current repertoire of models, offering genetic tractability in a vertebrate. Their retina has many similarities with a human retina. Importantly, unlike rodents, they have rich colour vision, offering the potential to model the macular degenerations. A variety of physiological assays, genetic manipulations and histological tools have been developed and useful models of human disease created.