PUBLICATION
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
- Authors
- Moon, H.S., Jacobson, E.M., Khersonsky, S.M., Luzung, M.R., Walsh, D.P., Xiong, W.N., Lee, J.W., Parikh, P.B., Lam, J.C., Kang, T.W., Rosania, G.R., Schier, A.F., and Chang, Y.T.
- ID
- ZDB-PUB-021112-2
- Date
- 2002
- Source
- Journal of the American Chemical Society 124(39): 11608-11609 (Journal)
- Registered Authors
- Jacobson, Eric, Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemical synthesis
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology
- Drug Screening Assays, Antitumor/methods
- Microtubules/drug effects*
- Purines/chemistry
- Purines/pharmacology
- Structure-Activity Relationship
- Triazines/chemical synthesis*
- Triazines/chemistry
- Triazines/pharmacology*
- Zebrafish/embryology*
- PubMed
- 12296721 Full text @ J. Am. Chem. Soc.
Citation
Moon, H.S., Jacobson, E.M., Khersonsky, S.M., Luzung, M.R., Walsh, D.P., Xiong, W.N., Lee, J.W., Parikh, P.B., Lam, J.C., Kang, T.W., Rosania, G.R., Schier, A.F., and Chang, Y.T. (2002) A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. Journal of the American Chemical Society. 124(39):11608-11609.
Abstract
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping