PUBLICATION
Zebrafish as a model for hearing and deafness
- Authors
- Whitfield, T.T.
- ID
- ZDB-PUB-021022-4
- Date
- 2002
- Source
- Journal of neurobiology 53(2): 157-171 (Review)
- Registered Authors
- Whitfield, Tanya T.
- Keywords
- zebrafish; ear; mutant; hearing; deafness
- MeSH Terms
-
- Animals
- Cloning, Molecular
- Deafness*/genetics
- Disease Models, Animal
- Ear, Inner/embryology*
- Ear, Inner/physiology*
- Genetic Techniques
- Genetic Testing
- Hearing*/genetics
- Mutagenesis
- Staining and Labeling
- Zebrafish*/genetics
- PubMed
- 12382273 Full text @ J. Neurobiol.
Citation
Whitfield, T.T. (2002) Zebrafish as a model for hearing and deafness. Journal of neurobiology. 53(2):157-171.
Abstract
The zebrafish is an especially attractive model for the study of the development and function of the vertebrate inner ear. It combines rapid and accessible embryogenesis with a host of genetic and genomic tools for systematic gene discovery and analysis. A large collection of mutations affecting development and function of the ear and a related sensory system, the lateral line, have been isolated; several of these have now been cloned, and at least five provide models for human deafness disorders. Disruption of multiple genes, using both forward and reverse genetic approaches, has established key players-both signaling molecules and autonomous factors-responsible for induction and specification of the otic placode. Vestibular and auditory defects have been detected in adult animals, making the zebrafish a useful system in which to tackle the genetic causes of late onset deafness and vestibular disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping