PUBLICATION
Characterization of unc-119 homologues in the zebrafish, Danio rerio
- Authors
- Manning, A.
- ID
- ZDB-PUB-021016-47
- Date
- 1999
- Source
- Master's Thesis : (Thesis)
- Registered Authors
- Manning, Angela
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Manning, A. (1999) Characterization of unc-119 homologues in the zebrafish, Danio rerio. Master's Thesis. .
Abstract
In C. elegans the unc-119 gene is expressed throughout the nervous system of both the embryo and adult and encodes a novel protein product (Maduto & Pilgrim, 1995). Due to its pan-neuronal expression it was thought that unc-119 would play a basic role in the development of the nematode nervous system. We wished to determine whether this family of genes is expressed during development and in non-retinal tissues in vertebrates. To address these questions we chose to investigate the expression pattern of the unc-119 homologue in the zebrafish. The zebrafish (Danio rerio) is a popular vertebrate model system that combines the ease of genetic manipulation with embryological analyses.
In this thesis, results are described that suggest there are at least three unc-119 homologues in the zebrafish genome. Two of these homologues (unc119b & unc119c) are expressed in non-retinal embryonic and adult tissues; the expression pattern of the third homologue, unc119a, has not been determined. These findings suggest that the unc-119 gene homologues in mammals (e.g. HRG4 and RRG4) may have a more widespread expression pattern (e.g. extra-retinal) than previously thought. (Abstract shortened by UMI.)
Errata / Notes
M.Sc. Thesis, University of Alberta (Canada)
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping