PUBLICATION

Vascular cell biology in vivo: a new piscine paradigm?

Authors
Weinstein, B.
ID
ZDB-PUB-020913-7
Date
2002
Source
Trends in cell biology   12(9): 439-445 (Review)
Registered Authors
Weinstein, Brant M.
Keywords
none
MeSH Terms
  • Angiography/methods
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors
  • Blood Vessels/anatomy & histology
  • Blood Vessels/physiology*
  • Embryo, Nonmammalian/anatomy & histology
  • Embryo, Nonmammalian/physiology
  • Green Fluorescent Proteins
  • In Situ Hybridization
  • Larva/anatomy & histology
  • Larva/physiology
  • Luminescent Proteins/genetics
  • Luminescent Proteins/metabolism
  • Neovascularization, Physiologic*
  • Proteins/genetics
  • Proteins/metabolism
  • Recombinant Fusion Proteins/genetics
  • Recombinant Fusion Proteins/metabolism
  • Zebrafish/anatomy & histology*
  • Zebrafish/genetics
  • Zebrafish/physiology*
  • Zebrafish Proteins*
PubMed
12220865 Full text @ Trends Cell Biol.
Abstract
Understanding how blood vessels form has become increasingly important in recent years yet remains difficult to study. The architecture and context of blood vessels are difficult to reproduce in vitro, and most developing blood vessels in vivo are relatively inaccessible to observation and experimental manipulation. Zebrafish, however, provide several advantages. They have small, accessible, transparent embryos and larvae, facilitating high-resolution imaging in vivo. In addition, genetic and experimental tools and methods are available for functional manipulation of the entire organism, vascular tissues or even single vascular- or non-vascular cells. Together, these features make the fish amenable to 'in vivo vascular cell biology'.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping