PUBLICATION

Arteries and veins: making a difference with zebrafish

Authors
Lawson, N.D. and Weinstein, B.M.
ID
ZDB-PUB-020912-15
Date
2002
Source
Nature reviews. Genetics   3(9): 674-682 (Review)
Registered Authors
Lawson, Nathan, Weinstein, Brant M.
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Arteries/physiology*
  • Chickens
  • Endothelium, Vascular/physiology
  • Mice
  • Morphogenesis
  • Veins/physiology*
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed
12209142 Full text @ Nat. Rev. Genet.
Abstract
Arteries and veins are structurally different and have long been functionally defined by the direction of blood flow that they carry. However, a growing body of evidence indicates that the identity of the endothelial cells that line these vessels is determined in the developing embryo, before circulation begins. Recent work on the zebrafish has led to the identification of signals that are responsible for arterial and venous differentiation of endothelial cells, and highlights the unique benefits of this model organism in the study of vascular development.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes