PUBLICATION
Arteries and veins: making a difference with zebrafish
- Authors
- Lawson, N.D. and Weinstein, B.M.
- ID
- ZDB-PUB-020912-15
- Date
- 2002
- Source
- Nature reviews. Genetics 3(9): 674-682 (Review)
- Registered Authors
- Lawson, Nathan, Weinstein, Brant M.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Arteries/physiology*
- Chickens
- Endothelium, Vascular/physiology
- Mice
- Morphogenesis
- Veins/physiology*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 12209142 Full text @ Nat. Rev. Genet.
Citation
Lawson, N.D. and Weinstein, B.M. (2002) Arteries and veins: making a difference with zebrafish. Nature reviews. Genetics. 3(9):674-682.
Abstract
Arteries and veins are structurally different and have long been functionally defined by the direction of blood flow that they carry. However, a growing body of evidence indicates that the identity of the endothelial cells that line these vessels is determined in the developing embryo, before circulation begins. Recent work on the zebrafish has led to the identification of signals that are responsible for arterial and venous differentiation of endothelial cells, and highlights the unique benefits of this model organism in the study of vascular development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping