PUBLICATION

Pseudocapillaria tomentosa, a nematode pathogen, and associated neoplasms of zebrafish (Danio rerio) kept in research colonies

Authors
Kent, M.L., Bishop-Stewart, J.K., Matthews, J.L., and Spitsbergen, J.M.
ID
ZDB-PUB-020701-2
Date
2002
Source
Comparative medicine   52(4): 354-358 (Journal)
Registered Authors
Bishop-Stewart, Janell, Kent, Michael, Matthews, Jennifer, Spitsbergen, Jan
Keywords
none
MeSH Terms
  • Animals
  • Animals, Laboratory
  • Female
  • Intestinal Neoplasms/parasitology
  • Intestinal Neoplasms/pathology
  • Intestinal Neoplasms/veterinary*
  • Male
  • Nematoda/anatomy & histology
  • Nematoda/physiology*
  • Nematode Infections/pathology
  • Nematode Infections/veterinary*
  • Zebrafish/parasitology*
PubMed
12211280
Abstract
Infections with capillarid nematodes were observed in zebrafish (Danio rerio) kept at several research facilities and in a large carcinogen exposure study previously conducted at Oregon State University. We report a morphologic description that identifies the worm as Pseudocapillaria tomentosa, a common nematode of cyprinid and other fishes. Pathologic lesions associated with the infection ranged from inflammatory changes to aggressive neoplasms of the intestine (i.e., intestinal carcinomas and mixed malignant neoplasms). Capillarid nematodes may have intermediate or paratenic hosts. Using a laboratory transmission study, we confirmed that the parasite has a direct life cycle.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes