ZFIN ID: ZDB-PUB-020610-2
Asymmetric expression of antivin/lefty1 in the early chick embryo
Ishimaru, Y., Yoshioka, H., Tao, H., Thisse, B., Thisse, C., Wright, C.V.E., Hamada, H. Ohuchi, H., and Noji, S.
Date: 2000
Source: Mechanisms of Development   90(1): 115-118 (Journal)
Registered Authors: Thisse, Bernard, Thisse, Christine, Wright, Christopher V.E.
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cell Polarity
  • Chick Embryo
  • Embryo, Nonmammalian/embryology
  • Embryo, Nonmammalian/physiology*
  • Gene Expression Regulation, Developmental*
  • Left-Right Determination Factors
  • Molecular Sequence Data
  • Sequence Alignment
  • Transforming Growth Factor beta/biosynthesis
  • Transforming Growth Factor beta/genetics*
PubMed: 10585569 Full text @ Mech. Dev.
Mammalian lefty and zebrafish antivin, highly related to lefty, are shown to be expressed asymmetrically and involved in the specification of the left body side of early embryos. We isolated a chick homologue of the antivin/lefty1 cDNA and studied its expression pattern during early chick development. We found that antivin/lefty1 is expressed asymmetrically on the left side of the prospective floorplate, notochord and lateral plate mesoderm of the chick embryo.