PUBLICATION
BIVM, a novel gene widely distributed among Deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia
- Authors
- Yoder, J.A., Hawke, N.A., Eason, D.D., Mueller, M.G., Davids, B.J., Gillin, F.D., and Litman, G.W.
- ID
- ZDB-PUB-020603-1
- Date
- 2002
- Source
- Genomics 79(6): 750-755 (Journal)
- Registered Authors
- Litman, Gary W., Mueller, Gail, Yoder, Jeffrey A.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 13*
- Conserved Sequence
- Gene Transfer, Horizontal
- Genome, Human*
- Giardia lamblia/genetics*
- Humans
- Immunoglobulins/genetics*
- Mice
- Molecular Sequence Data
- Organ Specificity
- Protozoan Proteins*
- Vertebrates/genetics*
- PubMed
- 12036287 Full text @ Genomics
Citation
Yoder, J.A., Hawke, N.A., Eason, D.D., Mueller, M.G., Davids, B.J., Gillin, F.D., and Litman, G.W. (2002) BIVM, a novel gene widely distributed among Deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia. Genomics. 79(6):750-755.
Abstract
A novel gene, BIVM (for basic, immunoglobulin-like variable motif-containing), has been identified using an electronic search based on the conservation of short sequence motifs within the variable region of immunoglobulin (Ig) genes. BIVM maps to human chromosome 13q32-q33 and is predicted to encode a 503-amino-acid protein with a pI of 9.1. The 5' untranslated region of BIVM is encoded in two exons; the coding portion is encoded in nine exons. BIVM is tightly linked (41 bp) and in the opposite transcriptional orientation to MGC5302 (also known as KDEL1 and EP58) in human. The ubiquitous expression of BIVM in normal tissues and the presence of a 5' CpG island suggest that BIVM is a housekeeping gene. Characterization of BIVM in representative species demonstrates significant conservation throughout deuterostomes; no sequence with significant identity to BIVM has been detected in proteostomes. However, an unusual gene has been identified in the protozoan pathogen Giardia lamblia that is similar to the core sequence of BIVM, suggesting the possibility of a horizontal gene transfer.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping