PUBLICATION
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
- Authors
- Wei, X. and Malicki, J.
- ID
- ZDB-PUB-020514-7
- Date
- 2002
- Source
- Nature Genetics 31(2): 150-157 (Journal)
- Registered Authors
- Malicki, Jarema, Wei, Xiangyun
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cell Differentiation/genetics
- Guanylate Kinases
- Intercellular Junctions/physiology
- Molecular Sequence Data
- Morphogenesis/genetics
- Nucleoside-Phosphate Kinase/genetics
- Nucleoside-Phosphate Kinase/physiology*
- Retina/embryology*
- Retina/physiology
- Zebrafish/embryology
- Zebrafish/genetics
- PubMed
- 11992120 Full text @ Nat. Genet.
Citation
Wei, X. and Malicki, J. (2002) nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nature Genetics. 31(2):150-157.
Abstract
A layered organization of cells is a common architectural feature of many neuronal formations. Mutations of the zebrafish gene nagie oko (nok) produce a severe disruption of retinal architecture, indicating a key role for this locus in neuronal patterning. We show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein. Nok localizes to the vicinity of junctional complexes in retinal neuroepithelium and in the photoreceptor cell layer. Mosaic analysis indicates that the nok retinal patterning phenotype is not cell-autonomous. We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping