PUBLICATION

Development of the zebrafish inner ear

Authors
Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B.
ID
ZDB-PUB-020403-2
Date
2002
Source
Developmental dynamics : an official publication of the American Association of Anatomists   223(4): 427-458 (Journal)
Registered Authors
Riley, Bruce, Whitfield, Tanya T.
Keywords
zebrafish; otic placode; otic vesicle; statoacoustic ganglion; lateral line; hair cell; supporting cell; hearing; balance; auditory; vestibular; cell death; retinoic acid; BMP; Claudins; Dach; Delta-Notch; Eya1; FGF; Krml1
MeSH Terms
  • Animals
  • Body Patterning
  • Ear, Inner/anatomy & histology
  • Ear, Inner/embryology
  • Ear, Inner/growth & development*
  • Epithelium
  • Humans
  • Morphogenesis
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed
11921334 Full text @ Dev. Dyn.
Abstract
Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes