PUBLICATION
Functional analysis of FGF3 during zebrafish inner ear development
- Authors
- Vendrell, V., Gimnopoulos, D., Becker, T., and Schimmang, T.
- ID
- ZDB-PUB-020307-1
- Date
- 2001
- Source
- The International journal of developmental biology : S105-S106 (Other)
- Registered Authors
- Becker, Thomas
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Vendrell, V., Gimnopoulos, D., Becker, T., and Schimmang, T. (2001) Functional analysis of FGF3 during zebrafish inner ear development. The International journal of developmental biology. :S105-S106.
Abstract
FGF3 has been involved in the development of the inner ear in a number of species including mouse, chicken and Xenopus. Initial experiments using antisense oligonucleotides in explants of chicken embryos indicated a role for FGF3 for proper formation of the otic vesicle (Represa et al., 1991). However, mice carrying a mutant FGF3 allele exhibited normal formation of the otic vesicle and only showed defects during later differentiation of the inner ear (Mansour et al., 1993). Implantation of beads incubated with FGF3 into Xenopus embryos led to the formation of ectopic vesicles (Lombardo et al., 1998). To further resolve the functions of FGF3 during inner ear development we recently performed gain-of- function experiments in chicken embryos by ectopically expressing FGF3 via a Herpes simplex-derived viral vector (Vendrell et al., 2000). Embryos infected by the virus developed ectopic otic vesicles confirming the involvement of FGF3 during formation of the otic vesicle in avians. To further clarify the role of FGF3 during inner ear development in vertebrates, we have now addressed its potential function in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping