|ZFIN ID: ZDB-PUB-011221-4|
Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons
Stuhmer, T., Puelles, L., Ekker, M., and Rubenstein, J.L.
|Source:||Cerebral cortex (New York, N.Y. : 1991) 12(1): 75-85 (Journal)|
|Registered Authors:||Ekker, Marc|
|Keywords:||Gaba immunoreactive neurons, medial ganglionic eminence, rat visual cortex, DLX genes, intermediate zone, binding proteins, branchial arches, basal forebrain, cerebral cortex, homeobox genes|
|PubMed:||11734534 Full text @ Cereb. Cortex|
Stuhmer, T., Puelles, L., Ekker, M., and Rubenstein, J.L. (2002) Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cerebral cortex (New York, N.Y. : 1991). 12(1):75-85.
ABSTRACTIn this paper we analyse the expression pattern of a zebrafish dlx4/6 enhancer/reporter construct in embryonic transgenic mice. We show that the pattern of LacZ/beta-galactosidase in cells that tangentially migrate from the ganglionic eminences to the cerebral cortex is identical to that of various subpallial markers, namely Dlx and GAD genes, that are known to label this population. Because beta-galactosidase activity persists long after expression of the Dlx genes and the transgene becomes undetectable, we were able to analyse the beta-galactosidase-positive cell population of the mature cortex through X-gal staining and immunohistochemistry. We show that this population is largely identical with the adult cortical and hippocampal interneuron population, providing further evidence for their subpallial origin.
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