PUBLICATION

Cardiac patterning and morphogenesis in zebrafish

Authors

Yelon, D.

ID

ZDB-PUB-011217-3

Date

2001

Source

Developmental Dynamics : an official publication of the American Association of Anatomists 222(4): 552-563 (Review)

Registered Authors

Yelon, Deborah

Keywords

heart tube formation, BHLH transcription factor, right axis formation, one-eyed pinhead, cardiovascular development, anteroposterior polarity, ventral morphogenesis, vertebrate heart, gene expression, tinman homologs

MeSH Terms

Animals
Body Patterning*
Embryo, Nonmammalian/physiology
Heart/embryology*
Zebrafish/embryology*

PubMed

11748825 Full text @ Dev. Dyn.

Abstract

Development of the embryonic vertebrate heart requires the precise coordination of pattern formation and cell movement. Taking advantage of the availability of zebrafish mutations that disrupt cardiogenesis, several groups have identified key regulators of specific aspects of cardiac patterning and morphogenesis. Several genes, including gata5, fgf8, bmp2b, one-eyed pinhead, and hand2, have been shown to be relevant to the patterning events that regulate myocardial differentiation. Studies of mutants with morphogenetic defects have indicated at least six genes that are essential for cardiac fusion and heart tube assembly, including casanova, bonnie and clyde, gata5, one-eyed pinhead, hand2, miles apart, and heart and soul. Furthermore, analysis of the jekyll gene has indicated its important role during the morphogenesis of the atrioventricular valve. Altogether, these data provide a substantial foundation for future investigations of cardiac patterning, cardiac morphogenesis, and the relationship between these processes.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Yelon, 2001 ZDB-PUB-011217-3 PMID:11748825

Cardiac patterning and morphogenesis in zebrafish

Yelon, 2001

ZDB-PUB-011217-3
PMID:11748825