ZFIN ID: ZDB-PUB-011214-4
The art and design of genetic screens: zebrafish
Patton, E.E. and Zon, L.I.
Date: 2001
Source: Nature reviews. Genetics   2(12): 956-966 (Review)
Registered Authors: Patton, E. Elizabeth, Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Genome*
  • Haploidy
  • Homozygote
  • Zebrafish/genetics*
PubMed: 11733748 Full text @ Nat. Rev. Genet.
Inventive genetic screens in zebrafish are revealing new genetic pathways that control vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish, biological processes that had been previously obscured can be visualized and many of the responsible genes can be isolated. Coupled with gene knockdown and overexpression technologies, and small-molecule-induced phenotypes, genetic screens in zebrafish provide a powerful system by which to dissect vertebrate gene function and gene networks.